Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Dec 2019)
The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study
- Nick A. Weaver,
- Lei Zhao,
- J. Matthijs Biesbroek,
- Hugo J. Kuijf,
- Hugo P. Aben,
- Hee‐Joon Bae,
- Miguel Á.A. Caballero,
- Francesca M. Chappell,
- Christopher P.L.H. Chen,
- Martin Dichgans,
- Marco Duering,
- Marios K. Georgakis,
- Ruben S. van derGiessen,
- Bibek Gyanwali,
- Olivia K.L. Hamilton,
- Saima Hilal,
- Elise M. vomHofe,
- Paul L.M. deKort,
- Peter J. Koudstaal,
- Bonnie Y.K. Lam,
- Jae‐Sung Lim,
- Stephen D.J. Makin,
- Vincent C.T. Mok,
- Lin Shi,
- Maria C. Valdés Hernández,
- Narayanaswamy Venketasubramanian,
- Joanna M. Wardlaw,
- Frank A. Wollenweber,
- Adrian Wong,
- Xu Xin,
- Meta VCI Map consortium,
- C. DeCarli,
- E.A. Fletcher,
- P. Maillard,
- J. Barnes,
- C.H. Sudre,
- J.M. Schott,
- M.A. Ikram,
- J.M. Papma,
- R.M.E. Steketee,
- M.W. Vernooij,
- R. Bordet,
- R. Lopes,
- C.‐W. Huang,
- R. Frayne,
- C.R. McCreary,
- E.E. Smith,
- Calgary Normative Study group,
- W. Backes,
- S. Köhler,
- R.J. vanOostenbrugge,
- J. Staals,
- F. Verhey,
- C.Y. Cheng,
- R.N. Kalaria,
- D. Werring,
- J.L. Hsu,
- K.‐L. Huang,
- J. van derGrond,
- J.W. Jukema,
- R.C. van derMast,
- T.C.W. Nijboer,
- Framingham Heart Study group,
- K.‐H. Yu,
- The Dutch Parelsnoer Institute – Neurodegenerative diseases group,
- R. Schmidt,
- L. Pirpamer,
- B.J. MacIntosh,
- A.D. Robertson,
- F.‐E. deLeeuw,
- A.M. Tuladhar,
- N. Chaturvedi,
- T. Tillin,
- H. Brodaty,
- P. Sachdev,
- TABASCO group,
- F. Barkhof,
- W.M. van derFlier,
- L.J. Kappelle,
- Geert Jan Biessels
Affiliations
- Nick A. Weaver
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Lei Zhao
- BrainNow Medical Technology Limited, Hong Kong Science and Technology ParkShatinHong Kong SARChina
- J. Matthijs Biesbroek
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Hugo J. Kuijf
- Image Sciences Institute, University Medical Center UtrechtUtrechtthe Netherlands
- Hugo P. Aben
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Hee‐Joon Bae
- Department of NeurologySeoul National University Bundang HospitalSeongnamRepublic of Korea
- Miguel Á.A. Caballero
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermany
- Francesca M. Chappell
- Neuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited Kingdom
- Christopher P.L.H. Chen
- Department of PharmacologyNational University of SingaporeSingaporeSingapore
- Martin Dichgans
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermany
- Marco Duering
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermany
- Marios K. Georgakis
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermany
- Ruben S. van derGiessen
- Department of NeurologyErasmus Medical CenterRotterdamthe Netherlands
- Bibek Gyanwali
- Department of PharmacologyNational University of SingaporeSingaporeSingapore
- Olivia K.L. Hamilton
- Neuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited Kingdom
- Saima Hilal
- Department of PharmacologyNational University of SingaporeSingaporeSingapore
- Elise M. vomHofe
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Paul L.M. deKort
- Department of NeurologyElisabeth Tweesteden HospitalTilburgthe Netherlands
- Peter J. Koudstaal
- Department of NeurologyErasmus Medical CenterRotterdamthe Netherlands
- Bonnie Y.K. Lam
- Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChina
- Jae‐Sung Lim
- Department of NeurologyHallym University Sacred Heart HospitalAnyangRepublic of Korea
- Stephen D.J. Makin
- Institute of Cardiovascular and Medical Sciences, University of GlasgowGlasgowUnited Kingdom
- Vincent C.T. Mok
- Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChina
- Lin Shi
- BrainNow Medical Technology Limited, Hong Kong Science and Technology ParkShatinHong Kong SARChina
- Maria C. Valdés Hernández
- Neuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited Kingdom
- Narayanaswamy Venketasubramanian
- Raffles Neuroscience Centre, Raffles HospitalSingaporeSingapore
- Joanna M. Wardlaw
- Neuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited Kingdom
- Frank A. Wollenweber
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermany
- Adrian Wong
- Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChina
- Xu Xin
- Department of PharmacologyNational University of SingaporeSingaporeSingapore
- Meta VCI Map consortium
- C. DeCarli
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- E.A. Fletcher
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- P. Maillard
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J. Barnes
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- C.H. Sudre
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J.M. Schott
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- M.A. Ikram
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J.M. Papma
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R.M.E. Steketee
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- M.W. Vernooij
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R. Bordet
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R. Lopes
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- C.‐W. Huang
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R. Frayne
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- C.R. McCreary
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- E.E. Smith
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Calgary Normative Study group
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- W. Backes
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- S. Köhler
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R.J. vanOostenbrugge
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J. Staals
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- F. Verhey
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- C.Y. Cheng
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R.N. Kalaria
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- D. Werring
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J.L. Hsu
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- K.‐L. Huang
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J. van derGrond
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- J.W. Jukema
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R.C. van derMast
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- T.C.W. Nijboer
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Framingham Heart Study group
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- K.‐H. Yu
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- The Dutch Parelsnoer Institute – Neurodegenerative diseases group
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- R. Schmidt
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- L. Pirpamer
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- B.J. MacIntosh
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- A.D. Robertson
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- F.‐E. deLeeuw
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- A.M. Tuladhar
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- N. Chaturvedi
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- T. Tillin
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- H. Brodaty
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- P. Sachdev
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- TABASCO group
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- F. Barkhof
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- W.M. van derFlier
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- L.J. Kappelle
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- Geert Jan Biessels
- Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe Netherlands
- DOI
- https://doi.org/10.1016/j.dadm.2019.02.007
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 310 – 326
Abstract
Abstract Introduction The Meta VCI Map consortium performs meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion‐symptom mapping studies. Methods Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results Forty‐seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population‐based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
Keywords
- Cerebrovascular disease
- Vascular cognitive impairment
- Stroke
- Small vessel disease
- Consortium
- Data harmonization
