Zhongguo youzhi (Aug 2024)

樟树籽仁油的遗传毒性评价

  • 彭婷1,2,3，梁丽军4，曾哲灵1,2,5，张淑虹1,5，鄢祥辉1,2,6，夏佳恒1,2,5，余平1,2,5， 万冬满1,2,3，文学方7,8 PENG Ting1,2,3, LIANG Lijun4, ZENG Zheling1,2,5, ZHANG Shuhong1,5, YAN Xianghui1,2,6, XIA Jiaheng1,2,5, YU Ping1,2,5, WAN Dongman1,2,3, WEN Xuefang7,8

DOI
https://doi.org/10.19902/j.cnki.zgyz.1003-7969.230201
Journal volume & issue
Vol. 49, no. 8
pp. 75 – 81

Abstract

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为评价樟树籽仁油的食用安全性，通过细菌回复突变试验、体外哺乳类细胞TK基因突变试验及哺乳动物红细胞微核试验探究樟树籽仁油的致突变和潜在致癌作用。结果表明：樟树籽仁油对组氨酸缺陷型鼠伤寒沙门氏菌TA1535、TA97、TA98、TA100、TA102均无致突变作用；樟树籽仁油未抑制L5178Y小鼠淋巴瘤细胞的生长，对体外哺乳类细胞TK基因无致突变作用；樟树籽仁油未导致小鼠细胞微核率上升，对哺乳动物红细胞无致突变作用，无遗传毒性。综上，樟树籽仁油无细胞致突变和潜在致癌作用，没有遗传毒性，具有一定的食用安全性。To evaluate the edible safety of Cinnamomum camphora seed kernel oil (CCSKO), the mutagenicity and potential carcinogenic effects of CCSKO were investigated by bacterial reverse mutation tests, in vitro mammalian cell TK gene mutation tests, and mammalian erythrocyte micronucleus tests. The results showed that CCSKO had no mutagenic effect on Salmonella typhimurium strains TA1535, TA97, TA98, TA100 and TA102 with histidine deficiency. CCSKO did not inhibit the growth of L5178Y mouse lymphoma cells, and had no mutagenic effect on TK gene in mammalian cells in vitro. CCSKO did not increase the micronucleus rate of cell in mice, had no mutagenic effect on mammalian erythrocytes and had no genotoxicity. To sum up, CCSKO has no mutagenicity and potential carcinogenic effect, no genotoxicity, and has certain edible safety.

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