Nature Communications (Jan 2022)

Modular assembly of the principal microtubule nucleator γ-TuRC

  • Martin Würtz,
  • Erik Zupa,
  • Enrico S. Atorino,
  • Annett Neuner,
  • Anna Böhler,
  • Ariani S. Rahadian,
  • Bram J. A. Vermeulen,
  • Giulia Tonon,
  • Sebastian Eustermann,
  • Elmar Schiebel,
  • Stefan Pfeffer

DOI
https://doi.org/10.1038/s41467-022-28079-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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The human microtubule nucleator γ-TuRC is composed of more than thirty subunits, including actin. Here the authors reveal the structural mechanism of modular γ-TuRC assembly and show a functional role of actin in microtubule nucleation.