Marked variation in heritability estimates of left ventricular mass depending on modality of measurement

Scientific Reports. 2019;9(1):1-8 DOI 10.1038/s41598-019-49961-w

 

Journal Homepage

Journal Title: Scientific Reports

ISSN: 2045-2322 (Online)

Publisher: Nature Publishing Group

LCC Subject Category: Medicine | Science

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Richard M. Nethononda (Division of Cardiology, Chris Hani Baragwanath Hospital, Soweto and the University of Witwatersrand)

Kathryn A. McGurk (Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester)

Polly Whitworth (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford)

Jane Francis (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford)

Chysovalanto Mamasoula (Institute of Genetic Medicine, Newcastle University)

Heather J. Cordell (Institute of Genetic Medicine, Newcastle University)

Stefan Neubauer (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford)

Bernard D. Keavney (Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester)

Bongani M. Mayosi (Department of Medicine, University of Cape Town)

Martin Farrall (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford)

Hugh Watkins (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 20 weeks

 

Abstract | Full Text

Abstract Left ventricular (LV) hypertrophy is a strong risk factor for heart failure and cardiovascular death. ECG measures of LV mass are estimated as heritable in twin and family-based analyses and heritability estimates of LV mass measured by echocardiography are lower. We hypothesised that CMR-derived measurements, being more precise than echocardiographic measurements, would advance our understanding of heritable LV traits. We phenotyped 116 British families (427 individuals) by CMR and ECG, and undertook heritability analyses using variance-components (QTDT) and GWAS SNP-based (GCTA-GREML) methods. ECG-based traits such as LV mass and Sokolow-Lyon duration showed substantial estimates of heritability (60%), whereas CMR-derived LV mass was only modestly heritable (20%). However, the ECG LV mass was positively correlated with the lateral diameter of the chest (rho = 0.67), and adjustment for this attenuated the heritability estimate (42%). Finally, CMR-derived right ventricular mass showed considerable heritability (44%). Heritability estimates of LV phenotypes show substantial variation depending on the modality of measurement, being greater when measured by ECG than CMR. This may reflect the differences between electrophysiological as opposed to anatomical hypertrophy. However, ECG LV hypertrophy traits are likely to be influenced by genetic association with anthropometric measures, inflating their overall measured heritability.