A Retrospective Analysis to Estimate the Burden of Invasive Pneumococcal Disease and Non-Invasive Pneumonia in Children <15 Years of Age in the Veneto Region, Italy
Elisa Barbieri,
Gloria Porcu,
Tianyan Hu,
Tanaz Petigara,
Francesca Senese,
Gian Marco Prandi,
Antonio Scamarcia,
Luigi Cantarutti,
Anna Cantarutti,
Carlo Giaquinto
Affiliations
Elisa Barbieri
Division of Paediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padua, Italy
Gloria Porcu
Unit of Biostatistics Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy
Tianyan Hu
Merck & Co. Inc., Kenilworth, NJ 07033, USA
Tanaz Petigara
Merck & Co. Inc., Kenilworth, NJ 07033, USA
Francesca Senese
MSD Italy, Via Vitorchiano 151, 00189 Rome, Italy
Gian Marco Prandi
MSD Italy, Via Vitorchiano 151, 00189 Rome, Italy
Antonio Scamarcia
Pedianet Project, 35138 Padua, Italy
Luigi Cantarutti
Pedianet Project, 35138 Padua, Italy
Anna Cantarutti
Unit of Biostatistics Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy
Carlo Giaquinto
Division of Paediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, 35128 Padua, Italy
Despite advances in preventative interventions, invasive pneumococcal disease and pneumonia cause significant morbidity and mortality in children. We studied the annual incidence of pneumococcal-specific and syndromic invasive disease and non-invasive pneumonia in children p = 0.46) throughout the study. Overall IR of non-invasive pneumonia was 10/1000 person-years and decreased significantly (−0.64, p = 0.026) over the study period. Following PCV13 introduction, the IRs of non-invasive pneumonia in children <15 years of age declined significantly, with no significant change in the IRs of pneumococcal-specific and syndromic invasive disease. There is a continuing clinical burden associated with pediatric pneumococcal diseases in Veneto, Italy.
