Toxicological assessment and risk management of nanoparticles mediated composite materials-critical review: state of the art

Abstract

Abstract Around the world, new composites, nanomaterial (NM) products, and tailored nanoparticles (NPs) are constantly being developed. Due to its many applications in the rapidly expanding field of nanotechnology, the manufacturing of nanoparticles is growing. NPs can efficiently migrate to the circulatory system, cross the blood–brain barrier, and have cellular and molecular effects on organs and tissues. There is a need to assess the potentially harmful effects of nanomaterials on plants, animals, microbes, surroundings, and more that will be brought to light in the future. Studies using a variety of model organisms have revealed the potential adverse effects associated with its widespread use. Further in-depth understanding of the toxicity of NPs, potential absorption pathways, and the harmful consequences they may have on living things is still needed. This review investigates the possible pathways of NPs, their potential for toxicity, and the underlying mechanisms that give rise to these effects. Furthermore, the review highlights existing gaps in risk assessment frameworks and underscores the importance of implementing comprehensive risk management strategies tailored to nanoparticle composites. These strategies aim to mitigate potential adverse effects while maximizing the benefits of nanotechnology-enabled materials. Since this topic hasn't been examined in a while, the current laws and regulations set forth by regulatory bodies that define the primary principles and requirements for evaluating novel nanomaterials will also be covered.

Keywords

• Nanoparticles
• Nanocomposites
• Model organisms
• Toxicity
• Nanotubes
• Regulatory framework