Structures in G proteins important for subtype selective receptor binding and subsequent activation

Abstract

With chimeric approach and biophysical (FRET) techniques, Jelinek, Mösslein & Bünemann elucidate coupling selectivity determinants of G proteins for two Gq-coupled receptors. They conclude that various regions, especially outside of the C-terminal tail of the Gα subunit, collectively affect G-protein-coupling selectivity.