IL-8 CHEMOTACTIC FACTOR IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AND FEATURES OF IL-8 GENE POLYMORPHISM (251 T/А)

Abstract

Fifty-four patients with different clinical course (acute and protracted forms) of community-acquired pneumonia (CAP), were studied for interleukin-8 (IL-8) contents in blood serum and its production levels (spontaneous and PHA-stimulated), depending on the IL-8 gene polymorphism at the 251 T → A locus. Employing the data about immunogenetic differences, we have shown some associations between IL-8 production, depending on clinical outcome (adequate responders vs poor response to medication in acute pneumonia). Both in acute and chronic forms of pneumonia, poor response to therapy was associated with decreased reserve capacity of IL-8 production, and a downward trend of cytokine concentration in blood serum. It was revealed that the CAP patients with poor response to treatment exhibit deficient production of IL-8 associated with homozygous AA genotype at the -251 T/A locus of IL-8 gene.

Keywords

• community-acquired pneumonia
• interleukin-8
• polymorphism of il-8 (locus of 251 t→a)