A survey of chiral hypervalent iodine reagents in asymmetric synthesis

Abstract

The recent years have witnessed a remarkable growth in the area of chiral hypervalent iodine chemistry. These environmentally friendly, mild and economic reagents have been used in catalytic or stoichiometric amounts as an alternative to transition metals for delivering enantioenriched molecules. Varieties of different chiral reagents and their use for demanding asymmetric transformations have been documented over the last 25 years. This review highlights the contribution of different chiral hypervalent iodine reagents in diverse asymmetric conversions.

Keywords

• alkene functionalization
• asymmetric synthesis
• hypervalent iodine
• organocatalysis
• oxidation