Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives
Dengxiong Li,
Qingxin Yu,
Ruicheng Wu,
Zhouting Tuo,
Jie Wang,
Luxia Ye,
Fanglin Shao,
Premkamon Chaipanichkul,
Koo Han Yoo,
Wuran Wei,
Uzoamaka Adaobi Okoli,
Shi Deng,
Mang Ke,
William C. Cho,
Susan Heavey,
Dechao Feng
Affiliations
Dengxiong Li
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China
Qingxin Yu
Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province, 315211, China
Ruicheng Wu
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China
Zhouting Tuo
Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China
Jie Wang
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China
Luxia Ye
Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China
Fanglin Shao
Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China
Premkamon Chaipanichkul
Division of Surgery & Interventional Science, University College London, London, UK
Koo Han Yoo
Department of Urology, Kyung Hee University, South Korea
Wuran Wei
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China
Uzoamaka Adaobi Okoli
Division of Surgery & Interventional Science, University College London, London, UK; Basic and Translational Cancer Research Group, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria
Shi Deng
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China
Mang Ke
Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China; Corresponding author.
William C. Cho
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China; Corresponding author.
Susan Heavey
Division of Surgery & Interventional Science, University College London, London, UK; Corresponding author.
Dechao Feng
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China; Division of Surgery & Interventional Science, University College London, London, UK; Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China; Corresponding author. Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Background: Recently, numerous studies have reported the interaction between senescence and oxidative stress in cancer. However, there is a lack of a comprehensive understanding of the precise mechanisms involved. Aim: Therefore, our review aims to summarize the current findings and elucidate by presenting specific mechanisms that encompass functional pathways, target genes, and related aspects. Methods: Pubmed and Web of Science databases were retrieved to search studies about the interaction between senescence and oxidative stress in cancer. Relevant publications in the reference list of enrolled studies were also checked. Results: In carcinogenesis, oxidative stress-induced cellular senescence acts as a barrier against the transformation of stimulated cells into cancer cells. However, the senescence-associated secretory phenotype (SASP) is positively linked to tumorigenesis. In the cancer progression stage, targeting specific genes or pathways that promote oxidative stress-induced cellular senescence can suppress cancer progression. In terms of treatment, many current clinical therapies combine with novel drugs to overcome resistance and reduce side effects by attenuating oxidative stress-induced senescence. Notably, emerging drugs control cancer development by enhancing oxidative stress-induced senescence. These studies highlight the complacted effects of the interplay between oxidative stress and senescence at different cancer stages and among distinct cell populations. Future research should focus on characterizing the roles of distinct senescent cell types in various tumor stages and identifying the specific components of SASP. Concludsion: We've summarized the mechanisms of senescence and oxidative stress in cancer and provided illustrative figures to guide future research in this area.
