Effects of yam and cassia seed vermicelli on blood lipid metabolism and antioxidation in dyslipidemia rats

Abstract

Objective To explore the effects of yam and cassia seed vermicelli on blood lipid metabolism and antioxidation in dyslipidemia rats. Methods Forty-eight SD rats were divided into model group (40 rats) and control group (8 rats). The rats in the model group were fed with high-fat diet for 4 weeks to establish a dyslipidemia rat model. 40 rats were randomly divided into model group, atorvastatin positive control group (10mg/kg/d), yam cassia seed vermicelli low, medium and high dose groups by random number method, with 8 rats in each group. After 5 weeks of intervention, a series of serum lipids index [total triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)]， liver body ratio, liver TG, TC, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) were measured. Results Compared to the model group, TC of serum, TC and TG of liver decreased by 14.76%, 23.75% and 39.69% in the medium dose group respectively, while SOD, GSH PX and T-AOC increased by 24.09%, 26.90% and 290.24% in the low dose group, respectively (P<0.05).The TG and LDL-C level of Serum were decreased in low, medium and high dose groups (P<0.05). Conclusion Yam and cassia seed vermicelli can reduce the blood lipid level and improve the antioxidant level in dyslipidemia rats. It has a certain application value in the adjuvant treatment of dyslipidemia and antioxidant.

Keywords

• yam
• cassia seed
• dyslipidemia
• blood lipid metabolism
• antioxidant