Frontiers in Medicine (Dec 2021)
Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS)
- Weiran Zhou,
- Yang Li,
- Yang Li,
- Yang Li,
- Yang Li,
- Yang Li,
- Yichun Ning,
- Yichun Ning,
- Yichun Ning,
- Yichun Ning,
- Yichun Ning,
- Shaomin Gong,
- Shaomin Gong,
- Shaomin Gong,
- Shaomin Gong,
- Shaomin Gong,
- Nana Song,
- Nana Song,
- Nana Song,
- Nana Song,
- Nana Song,
- Bowen Zhu,
- Jialin Wang,
- Jialin Wang,
- Jialin Wang,
- Jialin Wang,
- Jialin Wang,
- Shuan Zhao,
- Shuan Zhao,
- Shuan Zhao,
- Shuan Zhao,
- Shuan Zhao,
- Yiqin Shi,
- Yiqin Shi,
- Yiqin Shi,
- Yiqin Shi,
- Yiqin Shi,
- Xiaoqiang Ding,
- Xiaoqiang Ding,
- Xiaoqiang Ding,
- Xiaoqiang Ding,
- Xiaoqiang Ding
Affiliations
- Weiran Zhou
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yang Li
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yang Li
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Yang Li
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Yang Li
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Yang Li
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Yichun Ning
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yichun Ning
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Yichun Ning
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Yichun Ning
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Yichun Ning
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Shaomin Gong
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Shaomin Gong
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Shaomin Gong
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Shaomin Gong
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Shaomin Gong
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Nana Song
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Nana Song
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Nana Song
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Nana Song
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Nana Song
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Bowen Zhu
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Jialin Wang
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Jialin Wang
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Jialin Wang
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Jialin Wang
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Jialin Wang
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Shuan Zhao
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Shuan Zhao
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Shuan Zhao
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Shuan Zhao
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Shuan Zhao
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Yiqin Shi
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yiqin Shi
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Yiqin Shi
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Yiqin Shi
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Yiqin Shi
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- Xiaoqiang Ding
- Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Xiaoqiang Ding
- Shanghai Medical Center of Kidney Disease, Shanghai, China
- Xiaoqiang Ding
- Shanghai Institute of Kidney and Dialysis, Shanghai, China
- Xiaoqiang Ding
- Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China
- Xiaoqiang Ding
- Hemodialysis Quality Control Center of Shanghai, Shanghai, China
- DOI
- https://doi.org/10.3389/fmed.2021.782624
- Journal volume & issue
-
Vol. 8
Abstract
Background: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, this study estimated the prospective relationship of social isolation with rapid kidney function decline and the development of chronic kidney disease (CKD) in middle-aged and elderly Chinese with normal kidney function.Methods: We analyzed data from 3,031 participants aged ≥ 45 years with baseline estimated glomerular filtration rates (eGFR) ≥ 60 ml/min/1.73 m2. All data were obtained from the 2011 and 2015 waves of the Chinese Longitudinal Study of Health and Retirement (CHARLS). eGFR was estimated based on a combination of serum creatinine and cystatin C. The primary outcome was rapid decline in renal function, as defined by an eGFR decrease of > 5 ml/min/1.73 m2 per year, while the secondary outcome was the development of CKD, as defined by an eGFR decrease to a level < 60 ml/min/1.73 m2.Results: During the follow-up of 4 years, 258 (8.5%) participants experienced a rapid decline in renal function, while 87 (2.9%) developed CKD. In the fully adjusted model, high social isolation was significantly related to an increased risk of experiencing a rapid decline in renal function (OR 1.805, 95% CI 1.310–2.487) and CKD onset (OR 1.842, 95% CI 1.084–3.129). Among the five components of social isolation, being unmarried, not participating in social activities, and living alone independently predicted declined renal function.Conclusions: Social isolation is significantly associated with the risk of rapid eGFR decline and CKD onset in middle-aged and older adults with normal kidney function in China.
Keywords
- social isolation
- chronic kidney disease
- glomerular filtration rate
- CHARLS
- Chinese middle-aged and older adults
