Nature Communications (Jun 2017)
Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice
- Naoko Morimura,
- Hiroki Yasuda,
- Kazuhiko Yamaguchi,
- Kei-ichi Katayama,
- Minoru Hatayama,
- Naoko H. Tomioka,
- Maya Odagawa,
- Akiko Kamiya,
- Yoshimi Iwayama,
- Motoko Maekawa,
- Kazuhiko Nakamura,
- Hideo Matsuzaki,
- Masatsugu Tsujii,
- Kazuyuki Yamada,
- Takeo Yoshikawa,
- Jun Aruga
Affiliations
- Naoko Morimura
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- Hiroki Yasuda
- Education and Research Support Center, Gunma University Graduate School of Medicine
- Kazuhiko Yamaguchi
- Laboratory for Behavioral Genetics, RIKEN Brain Science Institute (BSI) Wako
- Kei-ichi Katayama
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- Minoru Hatayama
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- Naoko H. Tomioka
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- Maya Odagawa
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- Akiko Kamiya
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- Yoshimi Iwayama
- Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute (BSI) Wako
- Motoko Maekawa
- Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute (BSI) Wako
- Kazuhiko Nakamura
- Department of Neuropsychiatry, Hirosaki University School of Medicine
- Hideo Matsuzaki
- Research Center for Child Mental Development, University of Fukui
- Masatsugu Tsujii
- Faculty of Contemporary Sociology, Chukyo University
- Kazuyuki Yamada
- Support Unit for Animal Experiments, RIKEN Brain Science Institute (BSI) Wako
- Takeo Yoshikawa
- Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute (BSI) Wako
- Jun Aruga
- Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute (BSI) Wako
- DOI
- https://doi.org/10.1038/ncomms15800
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Lrfn2/SALM1 is a synaptic adhesion molecule, and is known to interact with PSD-95. Here the authors show that Lrfn2 regulates excitatory synapse maturation and maintenance, and that Lrfn2 knockout mice exhibit autism-like behaviours as well as enhanced learning and memory.
