Frontiers in Endocrinology (Jan 2022)

A Comparison of Two Hybrid Closed-Loop Systems in Italian Children and Adults With Type 1 Diabetes

  • Marta Bassi,
  • Marta Bassi,
  • Marsida Teliti,
  • Marilea Lezzi,
  • Marilea Lezzi,
  • Arianna Iosca,
  • Marina Francesca Strati,
  • Marina Francesca Strati,
  • Luca Carmisciano,
  • Giuseppe d’Annunzio,
  • Nicola Minuto,
  • Davide Maggi,
  • Davide Maggi,
  • Davide Maggi

DOI
https://doi.org/10.3389/fendo.2021.802419
Journal volume & issue
Vol. 12

Abstract

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Tandem Control-IQ and Minimed 780G represent the most Advanced Hybrid Closed Loop (AHCL) systems currently available in pediatric and adult subjects with Type 1 Diabetes (T1D). We retrospectively compared clinical and continuous glucose monitoring data from 51 patients who upgraded to Minimed 780G system and have completed 1-month observation period with data from 39 patients who upgraded to Tandem Control-IQ. Inverse probability weighting was used to minimize the basal characteristics imbalances. Both AHCL systems showed a significant improvement in glycemic parameters. Minimed 780G group achieved higher TIR increase (p= 0.004) and greater reduction of blood glucose average (p= 0.001). Tandem Control-IQ system significantly reduced the occurrence of TBR (p= 0.010) and the Coefficient of Variation of glucose levels (p= 0.005). The use of ACHL systems led to a significant improvement of glycemic control substantially reaching the International recommended glycemic targets. Minimed 780G appears to be more effective in managing hyperglycemia, while Tandem Control-IQ seems to be more effective in reducing time in hypoglycemia.

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