Nature Communications (Mar 2023)

UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs

  • Yue Hao,
  • Haowen Liu,
  • Xian-Ting Zeng,
  • Ya Wang,
  • Wan-Xin Zeng,
  • Kang-Ying Qian,
  • Lei Li,
  • Ming-Xuan Chi,
  • Shangbang Gao,
  • Zhitao Hu,
  • Xia-Jing Tong

DOI
https://doi.org/10.1038/s41467-023-37137-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

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The pre-and postsynaptic communication is critical for faithful synaptic transmission and induction of synaptic plasticity. Here, the authors found that CaMKII functions at GABAergic neurons to recruit GABAARs by triggering anterograde signals.