The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs

Dario Dattilo; Gaia Di Timoteo; Adriano Setti; Andrea Giuliani; Giovanna Peruzzi; Manuel Beltran Nebot; Alvaro Centrón-Broco; Davide Mariani; Chiara Mozzetta; Irene Bozzoni

doi:10.1038/s41467-023-37578-7

Nature Communications (Apr 2023)

The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs

Dario Dattilo,
Gaia Di Timoteo,
Adriano Setti,
Andrea Giuliani,
Giovanna Peruzzi,
Manuel Beltran Nebot,
Alvaro Centrón-Broco,
Davide Mariani,
Chiara Mozzetta,
Irene Bozzoni

Affiliations

Dario Dattilo: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome
Gaia Di Timoteo: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome
Adriano Setti: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome
Andrea Giuliani: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome
Giovanna Peruzzi: Center for Life Nano- & Neuro-Science@Sapienza, Fondazione Istituto Italiano di Tecnologia (IIT)
Manuel Beltran Nebot: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome
Alvaro Centrón-Broco: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome
Davide Mariani: Center for Human Technologies@Istituto Italiano di Tecnologia (IIT)
Chiara Mozzetta: Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy
Irene Bozzoni: Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome

DOI: https://doi.org/10.1038/s41467-023-37578-7
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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Rhabdomyosarcoma (RMS) is the most diffused soft tissue sarcoma in children and adolescents. Herein, the authors identify the m6A machinery and the RNA helicase DDX5 as factors responsible for the increase of a subset of circRNAs in RMS, providing protein and RNA candidates for the study of its tumorigenicity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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