Nature Communications (Nov 2020)

A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

  • Hao-Hsuan Hsieh,
  • Jae Ho Lee,
  • Sowmya Chandrasekar,
  • Shu-ou Shan

DOI
https://doi.org/10.1038/s41467-020-19548-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 20

Abstract

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Biochemistry combined with biophysical measurements and mathematical modeling offer insight into the mechanism by which the cotranslational chaperone, nascent polypeptide-associated complex (NAC), modulates substrate selection by signal recognition particle (SRP) and reduces aberrant, nonspecific targeting of ribosomes to the ER.