Marine Drugs
(Dec 2015)
Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
Yin-Di Su,
Tung-Ying Wu,
Zhi-Hong Wen,
Ching-Chyuan Su,
Yu-Hsin Chen,
Yu-Chia Chang,
Yang-Chang Wu,
Jyh-Horng Sheu,
Ping-Jyun Sung
Affiliations
Yin-Di Su
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Tung-Ying Wu
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Ching-Chyuan Su
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
Yu-Hsin Chen
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Yu-Chia Chang
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Yang-Chang Wu
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Jyh-Horng Sheu
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Ping-Jyun Sung
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
DOI
https://doi.org/10.3390/md13127060
Journal volume & issue
Vol. 13,
no. 12
Abstract
Read online
Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (1–5), were isolated from the octocoral Briareum sp. The structures of briaranes 1–5 were elucidated by spectroscopic methods. Briarenolides U–Y (1–5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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