Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Ryo Nakamichi; Yoshiaki Ito; Masafumi Inui; Naoko Onizuka; Tomohiro Kayama; Kensuke Kataoka; Hidetsugu Suzuki; Masaki Mori; Masayo Inagawa; Shizuko Ichinose; Martin K. Lotz; Daisuke Sakai; Koichi Masuda; Toshifumi Ozaki; Hiroshi Asahara

doi:10.1038/ncomms12503

Nature Communications (Aug 2016)

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Ryo Nakamichi,
Yoshiaki Ito,
Masafumi Inui,
Naoko Onizuka,
Tomohiro Kayama,
Kensuke Kataoka,
Hidetsugu Suzuki,
Masaki Mori,
Masayo Inagawa,
Shizuko Ichinose,
Martin K. Lotz,
Daisuke Sakai,
Koichi Masuda,
Toshifumi Ozaki,
Hiroshi Asahara

Affiliations

Ryo Nakamichi: Department of Systems Biomedicine, Tokyo Medical and Dental University
Yoshiaki Ito: Department of Systems Biomedicine, Tokyo Medical and Dental University
Masafumi Inui: Department of Systems Biomedicine, National Research Institute for Child Health and Development
Naoko Onizuka: Department of Systems Biomedicine, National Research Institute for Child Health and Development
Tomohiro Kayama: Department of Systems Biomedicine, Tokyo Medical and Dental University
Kensuke Kataoka: Department of Systems Biomedicine, Tokyo Medical and Dental University
Hidetsugu Suzuki: Department of Systems Biomedicine, Tokyo Medical and Dental University
Masaki Mori: Department of Systems Biomedicine, Tokyo Medical and Dental University
Masayo Inagawa: Department of Systems Biomedicine, National Research Institute for Child Health and Development
Shizuko Ichinose: Research Center for Medical and Dental Sciences, Tokyo Medical and Dental University
Martin K. Lotz: Department of Molecular and Experimental Medicine, The Scripps Research Institute
Daisuke Sakai: Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine
Koichi Masuda: University of California, San Diego
Toshifumi Ozaki: Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Hiroshi Asahara: Department of Systems Biomedicine, Tokyo Medical and Dental University

DOI: https://doi.org/10.1038/ncomms12503
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Homeobox protein Mohwak (Mkx) is involved in tendon and ligament development. Here the authors show that Mkx in the outer annulus fibrosus of the intervertebral disc plays a role in maintenance of the IVD, showing that stem cells overexpressing Mkx enhance therapeutic IVD regeneration in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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