Secondary metabolites from the cold-seep-derived fungus Penicillium sp. SCSIO 41425 and their free radical scavenging activity

Yi Chen; Ying Liu; Jianglian She; Mengjing Cong; Junfeng Wang; Lalith Jayasinghe; Yonghong Liu; Xuefeng Zhou

Journal of Holistic Integrative Pharmacy (Dec 2024)

Secondary metabolites from the cold-seep-derived fungus Penicillium sp. SCSIO 41425 and their free radical scavenging activity

Yi Chen,
Ying Liu,
Jianglian She,
Mengjing Cong,
Junfeng Wang,
Lalith Jayasinghe,
Yonghong Liu,
Xuefeng Zhou

Affiliations

Yi Chen: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, Beijing, 100049, China
Ying Liu: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China
Jianglian She: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, Beijing, 100049, China
Mengjing Cong: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, Beijing, 100049, China
Junfeng Wang: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, Beijing, 100049, China
Lalith Jayasinghe: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; National Institute of Fundamental Studies, Hantana Road, Kandy, 200000, Sri Lanka
Yonghong Liu: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, Beijing, 100049, China
Xuefeng Zhou: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Corresponding author. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.

Journal volume & issue: Vol. 5, no. 4
pp. 257 – 261

Abstract

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Objective: To study the chemical compositions from Penicillium sp. SCSIO 41425 and explore their DPPH radical scavenging activity. Methods: Ethyl acetate extract of Penicillium sp. SCSIO 41425 was separated and purified by silica gel, Ostade-cylsilane (ODS), semi-preparative HPLC, and thin layer chromatography, and their structures were determined by spectroscopic analysis and comparison with the reported literatures. Results: A total of 18 compounds were isolated from Penicillium sp. SCSIO 41425, including one new compound, (2′R,3′R)-4-(3-hydroxybutan-2-yl)-3,6-dimethylbenzene-1,2-diol (1) and seventeen known compounds (2–18). Their structures were elucidated by detailed NMR and ECD calculations. Compounds 4 and 5 exhibited potent DPPH radical scavenging activity, with EC50 values of 8.42 and 6.62 μg/mL, which were stronger than the positive control ascorbic acid (EC50, 11.22 μg/mL). Conclusion: This study expands the natural product library of marine cold-seep-derived fungus and provides marine-derived drug source molecules for potent antioxidants.

Published in Journal of Holistic Integrative Pharmacy

ISSN: 2707-3688 (Print); 2950-175X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Pharmacy and materia medica; Medicine: Therapeutics. Pharmacology
Website: https://www.keaipublishing.com/en/journals/journal-of-holistic-integrative-pharmacy/

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