Nature Communications (Apr 2023)
Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure
- Jae Woo Park,
- Eun Roh,
- Gil Myoung Kang,
- So Young Gil,
- Hyun Kyong Kim,
- Chan Hee Lee,
- Won Hee Jang,
- Se Eun Park,
- Sang Yun Moon,
- Seong Jun Kim,
- So Yeon Jeong,
- Chae Beom Park,
- Hyo Sun Lim,
- Yu Rim Oh,
- Han Na Jung,
- Obin Kwon,
- Byung Soo Youn,
- Gi Hoon Son,
- Se Hee Min,
- Min-Seon Kim
Affiliations
- Jae Woo Park
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Eun Roh
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital
- Gil Myoung Kang
- Appetite Regulation Laboratory, Asan Institute for Life Science
- So Young Gil
- Appetite Regulation Laboratory, Asan Institute for Life Science
- Hyun Kyong Kim
- Appetite Regulation Laboratory, Asan Institute for Life Science
- Chan Hee Lee
- Program of Material Science for Medicine and Pharmaceutics, Hallym University
- Won Hee Jang
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Se Eun Park
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Sang Yun Moon
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Seong Jun Kim
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- So Yeon Jeong
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Chae Beom Park
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Hyo Sun Lim
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Yu Rim Oh
- Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine
- Han Na Jung
- Appetite Regulation Laboratory, Asan Institute for Life Science
- Obin Kwon
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Byung Soo Youn
- OsteoNeuroGen
- Gi Hoon Son
- Department of Biomedical Science, Korea University College of Medicine
- Se Hee Min
- Appetite Regulation Laboratory, Asan Institute for Life Science
- Min-Seon Kim
- Appetite Regulation Laboratory, Asan Institute for Life Science
- DOI
- https://doi.org/10.1038/s41467-023-37517-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Nicotinamide phosphoribosyl transferase (NAMPT) is a critical regulator of cellular nicotinamide adenine dinucleotide (NAD)+ levels. Here, the authors show that blood NAMPT contributes to the circadian rhythm generation of locomotor activity and energy expenditure by regulating hypothalamic NAD+ levels.
