Nature Communications (Jun 2019)

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

  • Juan José Martínez-García,
  • Helios Martínez-Banaclocha,
  • Diego Angosto-Bazarra,
  • Carlos de Torre-Minguela,
  • Alberto Baroja-Mazo,
  • Cristina Alarcón-Vila,
  • Laura Martínez-Alarcón,
  • Joaquín Amores-Iniesta,
  • Fátima Martín-Sánchez,
  • Giovanni A. Ercole,
  • Carlos M. Martínez,
  • Ada González-Lisorge,
  • José Fernández-Pacheco,
  • Piedad Martínez-Gil,
  • Sahil Adriouch,
  • Friedrich Koch-Nolte,
  • Juan Luján,
  • Francisco Acosta-Villegas,
  • Pascual Parrilla,
  • Carlos García-Palenciano,
  • Pablo Pelegrin

DOI
https://doi.org/10.1038/s41467-019-10626-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome in establishing a host response, and NLRP3 dysfunction is a common feature of sepsis mortality.