SUPEROxIDE DISMUTASE AS A COMPONENT OF ANTIOxIDANT THERAPY: CURRENT STATE OF THE ISSUE AND PROSPECTS. A LITERATURE REVIEW

Abstract

Oxidative stress, developing in many diseases, is an imbalance between pro-oxidants and antioxidant defense mechanisms of the body. Antioxidant enzymes such as superoxide dismutase (SOD) play a key role in reduction of oxidative stress in vivo. Thus, a decrease in formation of reactive oxygen species (ROS), as well as activation of lipid peroxidation (LPO) due to exogenous SOD intake could be an effective method of prevention and treatment of some diseases. In this paper, we provide an overview of the results of experimental and clinical studies on the use of intravenous drugs and dietary supplements, containing SOD, in the treatment of inflammatory, infectious, cardiovascular and neurodegenerative diseases. As a result of SOD administration, the majority of authors observed an increase in the content of endogenous antioxidant enzymes (SOD, catalase, glutathione peroxidase), i.e., stimulation of endogenous antioxidant defence and consequent reduction of oxidative stress, which may explain mechanisms of positive effects observed.

Keywords

• oxidative stress
• antioxidants
• superoxide dismutase
• antioxidant enzymes
• catalase
• glutathione peroxidase
• experiments
• clinic