Nature Communications (Aug 2021)

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

  • Makoto Yamagishi,
  • Miyuki Kubokawa,
  • Yuta Kuze,
  • Ayako Suzuki,
  • Akari Yokomizo,
  • Seiichiro Kobayashi,
  • Makoto Nakashima,
  • Junya Makiyama,
  • Masako Iwanaga,
  • Takahiro Fukuda,
  • Toshiki Watanabe,
  • Yutaka Suzuki,
  • Kaoru Uchimaru

DOI
https://doi.org/10.1038/s41467-021-25101-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Characterising the clonal architecture of Adult T-cell leukemia-lymphoma (ATL) remains crucial. Here, the authors develop a capture-based sequencing panel and use deep DNA and single cell RNA sequencing and report distinct genomic and transcriptomic features associated with subclonal evolution.