Nature Communications (Apr 2016)
Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
- John M. Findlay,
- Francesc Castro-Giner,
- Seiko Makino,
- Emily Rayner,
- Christiana Kartsonaki,
- William Cross,
- Michal Kovac,
- Danny Ulahannan,
- Claire Palles,
- Richard S. Gillies,
- Thomas P. MacGregor,
- David Church,
- Nicholas D. Maynard,
- Francesca Buffa,
- Jean-Baptiste Cazier,
- Trevor A. Graham,
- Lai-Mun Wang,
- Ricky A. Sharma,
- Mark Middleton,
- Ian Tomlinson
Affiliations
- John M. Findlay
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Francesc Castro-Giner
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Seiko Makino
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Emily Rayner
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Christiana Kartsonaki
- Department of Oncology, Old Road Campus Research Building
- William Cross
- Evolution and Cancer Laboratory, Bart’s Cancer Institute, Queen Mary University of London, Charterhouse Square
- Michal Kovac
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Danny Ulahannan
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Claire Palles
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Richard S. Gillies
- Oxford Oesophagogastric Centre, Churchill Hospital, Oxford University Hospitals NHS Trust
- Thomas P. MacGregor
- Oxford Oesophagogastric Centre, Churchill Hospital, Oxford University Hospitals NHS Trust
- David Church
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- Nicholas D. Maynard
- Oxford Oesophagogastric Centre, Churchill Hospital, Oxford University Hospitals NHS Trust
- Francesca Buffa
- Department of Oncology, Old Road Campus Research Building
- Jean-Baptiste Cazier
- Centre for Computational Biology, Haworth Building, and School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham
- Trevor A. Graham
- Evolution and Cancer Laboratory, Bart’s Cancer Institute, Queen Mary University of London, Charterhouse Square
- Lai-Mun Wang
- Department of Cellular Pathology, John Radcliffe Hospital, Oxford University Hospitals NHS Trust
- Ricky A. Sharma
- Department of Oncology, Old Road Campus Research Building
- Mark Middleton
- Department of Oncology, Old Road Campus Research Building
- Ian Tomlinson
- Molecular and Population Genetics Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive
- DOI
- https://doi.org/10.1038/ncomms11111
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Oesophageal adenocarcinoma is often treated with chemotherapy before surgery. Here, the authors sequence cancer samples before and after chemotherapy and examine how the genome changes, focusing on changes in driver gene mutations and differential clonal evolution between good and poor responders.
