Children with congenital Zika syndrome: symptoms, comorbidities and gross motor development at 24 months of ageWhat this paper adds?
Lêda Maria da Costa Pinheiro Frota,
Rosana Ferreira Sampaio,
José Lucivan Miranda,
Rita Maria Cavalcante Brasil,
Ana Paula Bensemann Gontijo,
Juliana Vaz de Melo Mambrini,
Marina de Brito Brandão,
Marisa Cotta Mancini
Affiliations
Lêda Maria da Costa Pinheiro Frota
Interinstitutional Doctorate Program (Dinter) UFC-UFMG Graduate Program in Rehabilitation Sciences, Universidade Federal de Minas Gerais, Center for Treatment and Early Stimulation - NUTEP, Rua - Papi Júnior, 1225, Rodolfo Teófilo,60, 430-235, Fortaleza, Ceará, Brazil
Rosana Ferreira Sampaio
Department of Physical Therapy, Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Campus Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
José Lucivan Miranda
Department of Maternal and Child Health. Universidade Federal do Ceará, Center for Treatment and Early Stimulation - NUTEP, Rua -Papi Júnior, 1225, Rodolfo Teófilo, 60, 430-235, Fortaleza, Ceará, Brazil
Rita Maria Cavalcante Brasil
Center for Treatment and Early Stimulation - NUTEP, Rua Papi Júnior, 1225, Rodolfo Teófilo, 60, 430-235, Fortaleza, Ceará, Brazil
Ana Paula Bensemann Gontijo
Department of Physical Therapy, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais. Av. Antonio Carlos 6627, Campus Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Juliana Vaz de Melo Mambrini
Oswaldo Cruz Foundation's René Rachou Institute (IRR) (Fiocruz), Belo Horizonte, Minas Gerais, Brazil
Marina de Brito Brandão
Department of Occupational Therapy, Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Campus Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Marisa Cotta Mancini
Department of Occupational Therapy, Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational Therapy, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Campus Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil; Corresponding author.
Background: Children with congenital Zika syndrome (CZS) maintain severe motor impairments at the end of the first year of life. Presence of certain symptoms and comorbidities increase these children's vulnerability. Aims: To evaluate gross motor function of a group of Brazilian children with CZS at 24 months of age and to investigate the association between the presence of CZS symptoms and comorbidities with gross motor development. Methods and procedures: Fifty children with CZS participated in the study. Information was collected from medical charts, and gross motor development was evaluated by the Gross Motor Function Measure (GMFM)-88. GMFM-88 scores were compared among comorbid groups. Three subgroups of children were identified by cluster analysis, based on information from head circumference at birth, symptoms, comorbidities and gross motor function. Outcomes and results: Significant associations (p < 0.001) were observed between number of comorbidities/symptoms and dimensions A (r = -0.57) and B (r = -0.58) of the GMFM-88. Children were grouped into 3 clusters, with different gross motor skills. Children with epilepsy and dysphagia composed the cluster with smaller median scores for dimensions A and B of the GMFM-88. Conclusions and implications: The presence of CZS symptoms and comorbidities compromise the gross motor repertoire of children with CZS at 24 months.
