Data in Brief
(Dec 2017)
Data on atherosclerosis specific antibody conjugation to nanoemulsions
- Geoffrey Prévot,
- Martine Duonor-Cérutti,
- Mélusine Larivière,
- Jeanny Laroche-Traineau,
- Marie Josée Jacobin-Valat,
- Philippe Barthélémy,
- Gisèle Clofent-Sanchez,
- Sylvie Crauste-Manciet
Affiliations
- Geoffrey Prévot
- Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN: Régulations Naturelle et Artificielle, ChemBioPharm, F-33000 Bordeaux, France
- Martine Duonor-Cérutti
- CNRS UPS3044, Baculovirus et Thérapie, F-30380 Saint-Christol-lès-Alès, France
- Mélusine Larivière
- Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France
- Jeanny Laroche-Traineau
- Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France
- Marie Josée Jacobin-Valat
- Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France
- Philippe Barthélémy
- Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN: Régulations Naturelle et Artificielle, ChemBioPharm, F-33000 Bordeaux, France
- Gisèle Clofent-Sanchez
- Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France
- Sylvie Crauste-Manciet
- Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN: Régulations Naturelle et Artificielle, ChemBioPharm, F-33000 Bordeaux, France; Corresponding author.
- Journal volume & issue
-
Vol. 15
pp.
824
– 827
Abstract
Read online
This article present data related to the publication entitled âIron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imagingâ (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide). Atheroma labelling was assayed by immunochemistry on arterial sections from rabbits.
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