Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk
Santosh D. Bhosale,
Robert Moulder,
Tomi Suomi,
Terhi Ruohtula,
Jarno Honkanen,
Suvi M. Virtanen,
Jorma Ilonen,
Laura L. Elo,
Mikael Knip,
Riitta Lahesmaa
Affiliations
Santosh D. Bhosale
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Robert Moulder
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
Tomi Suomi
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
Terhi Ruohtula
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Jarno Honkanen
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Suvi M. Virtanen
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Center for Child Health Research and Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland
Jorma Ilonen
Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
Laura L. Elo
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland
Mikael Knip
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research and Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland
Riitta Lahesmaa
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland; Corresponding author
Summary: In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with perinatal proteomes could reveal further biological perspectives. Accordingly, to determine differences between feeding groups and changes in infancy, serum proteomics analyses of mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes (n = 22), weaned to either an extensively hydrolyzed or regular cow’s milk formula, were made. The LC-MS/MS analyses included samples from the beginning of third trimester, the time of delivery, 3 months postpartum, cord blood, and samples from the infants at 3, 6, 9, and 12 months. Correlations between ranked protein intensities were detected within the dyads, together with perinatal and age-related changes. Comparison with intestinal permeability data revealed a number of significant correlations, which could merit further consideration in this context.
