GENDER AND AGE DIFFERENCES OF BRAIN NATRIURETIC PEPTIDE CONCENTRATION IN PATIENTS WITH MYOCARDIAL INFARCTION

Abstract

Aim. To measure the changes in brain natriuretic peptide (NT-proBNP) in patients with acute myocardial infarction with ST segment elevation (STEMI) according to the age and gender Material and methods. Totally 223 patients with STEMI included, of those 167 (74,88%) were men and 56 (25,11%) women. Average age of women was 61,80 (57;68) years, of men — 57,15 (51;63) years (p=0,0003). The follow-up period starting during hospitalization included 12 months of outpatient treatment. After 12 months the endpoints were assessed. The NT-proBNP concentration was measured on 10-14th day after infarction using serum by testing system "BIOMEDICA GRUPPE". Results. In women from older group NT-proBNP concentration was higher than in younger patients by 38%, in men — by 57,31%. In men with poor prognosis level of NT-proBNP was significantly higher (96,35 fM/ml) comparing to those with benign prognosis (63,8), p=0,0108. There were no such differences in women.Conclusion. Trustworthy differences of the biomarker studied between men and women do not exist, however in men and in women either of older group (more than 65) there are higher levels of NT-proBNP, than in younger group. Also men with poor prognosis in higher age group do have the highest NT-proBNP level.

Keywords

• differences
• age
• brain natriuretic peptide