Connecting high-resolution 3D chromatin organization with epigenomics

Abstract

While large-scale 3D genome architecture is well studied, the limits of resolution have hindered our understanding on the fine scale. Here the authors mapped 1D epigenomic profiles to fine-scale 3D chromatin structures with their deep learning model CAESAR. The model predicted fine-scale structures, such as short-range chromatin loops and stripes, that Hi-C datasets fail to detect.