Features of transfusion therapy in patients undergoing hematopoietic stem cell transplantation. Review of the literature

Abstract

The indications for transfusion of blood components support after stem cell transplantation (SCT) usually do not differ form other clinical situations, but the rules for such therapy have a number of features. One of them is the possibility of inconsistence of AB0 group between donor and recipient of hematopoietic stem cells, which is not only fraught with the development of various alloimmune complications, but also fundamentally changes the standards for the selection of blood components for transfusion. A major problem after HSCT is a secondary immunodeficiency, which is important to consider for ensuring prevention of transfusion-transmitted infections (eg, CMV), as well as to carry out activities aimed for the prevention of transfusion- associated graft-versus-host disease. HSCT is a medical technology today, the effectiveness of which is often dependent on the accuracy and integrity of its implementation. So, serious attitude to various supportive therapy, including transfusions of blood components is an important component which determines the success of the treatment.

Keywords

• hemopoietic stem cell transplantation
• transfusion therapy,
• hemolysis
• alloimmunization
• transfusion-associated graft-versushost disease