Prevalence of Hypofibrinogenemia Among Patients With Acute Gastrointestinal Bleeding: A Cross-Sectional Study

Abstract

Objectives: Hypofibrinogenemia can worsen the outcome of patients with gastrointestinal bleeding (GIB). There are a few domestic surveys on the issue. We conducted this study to evaluate the prevalence of hypofibrinogenemia and its effect on the outcome of patients with acute GIB. Materials and Methods: In this cross-sectional study, all data about the patients with acute GIB admitted to the emergency departments of hospitals of Shahid Beheshti University of Medical sciences in 2016 were collected and analyzed using SPSS statistical software version 21.0 and all tests were considered significant at P value ≤ 0.05. Results: From the patients under the study, 69% were male and the mean age was 53.38±13.18 years old. Mean levels of haemoglobin, international normalized ratio (INR), and fibrinogen were 10.68, 1.65, and 250.43, respectively. Moreover, most cases of hypofibrinogenemia had liver disorders or lower GIB (P<0.05). While, fibrinogen level had no significant effect on mortality. Conclusions: In summary, afibrinogenemia is mostly correlated with liver diseases and lower GIB, and can cause severe morbidity.

Keywords

• hypofibrinogenemia
• gastrointestinal bleeding
• fibrinogen
• blood