Cancers (Apr 2024)
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project)
- Mario Serradilla-Martín,
- Celia Villodre,
- Laia Falgueras-Verdaguer,
- Natalia Zambudio-Carroll,
- José T. Castell-Gómez,
- Juan L. Blas-Laina,
- Vicente Borrego-Estella,
- Carlos Domingo-del-Pozo,
- Gabriel García-Plaza,
- Francisco J. González-Rodríguez,
- Eva M. Montalvá-Orón,
- Ángel Moya-Herraiz,
- Sandra Paterna-López,
- Miguel A. Suárez-Muñoz,
- Maialen Alkorta-Zuloaga,
- Gerardo Blanco-Fernández,
- Enrique Dabán-Collado,
- Miguel A. Gómez-Bravo,
- José I. Miota-de-Llamas,
- Fernando Rotellar,
- Belinda Sánchez-Pérez,
- Santiago Sánchez-Cabús,
- David Pacheco-Sánchez,
- Juan C. Rodríguez-Sanjuan,
- María A. Varona-Bosque,
- Lucía Carrión-Álvarez,
- Sofía de la Serna-Esteban,
- Cristina Dopazo,
- Elena Martín-Pérez,
- David Martínez-Cecilia,
- María J. Castro-Santiago,
- Dimitri Dorcaratto,
- Marta L. Gutiérrez-Díaz,
- José M. Asencio-Pascual,
- Fernando Burdío-Pinilla,
- Roberto Carracedo-Iglesias,
- Alfredo Escartín-Arias,
- Benedetto Ielpo,
- Gonzalo Rodríguez-Laiz,
- Andrés Valdivieso-López,
- Emilio De-Vicente-López,
- Vicente Alonso-Orduña,
- José M. Ramia
Affiliations
- Mario Serradilla-Martín
- Department of Surgery, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain
- Celia Villodre
- Department of Surgery, Hospital General Universitario Dr. Balmis, 03010 Alicante, Spain
- Laia Falgueras-Verdaguer
- Department of Surgery, Hospital Universitario Dr. Josep Trueta, 17007 Girona, Spain
- Natalia Zambudio-Carroll
- Department of Surgery, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain
- José T. Castell-Gómez
- Department of Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain
- Juan L. Blas-Laina
- Department of Surgery, Hospital Royo Villanova, 50015 Zaragoza, Spain
- Vicente Borrego-Estella
- Department of Surgery, Hospital Universitario Lozano Blesa, 50009 Zaragoza, Spain
- Carlos Domingo-del-Pozo
- Department of Surgery, Hospital Universitario Dr. Peset, 46017 Valencia, Spain
- Gabriel García-Plaza
- Department of Surgery, Hospital Universitario Insular, 35016 Las Palmas de Gran Canaria, Spain
- Francisco J. González-Rodríguez
- Department of Surgery, Hospital Clínico Universitario de Santiago, 15706 Santiago de Compostela, Spain
- Eva M. Montalvá-Orón
- Department of Surgery, Hospital Universitario y Politécnico La Fe, IIS La Fe, Ciberehd ISCIII, 46026 Valencia, Spain
- Ángel Moya-Herraiz
- Department of Surgery, Hospital Universitario de Castellón, 12004 Castelló de la Plana, Spain
- Sandra Paterna-López
- Department of Surgery, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
- Miguel A. Suárez-Muñoz
- Department of Surgery, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain
- Maialen Alkorta-Zuloaga
- Department of Surgery, Hospital Universitario Donostia, 20014 San Sebastián, Spain
- Gerardo Blanco-Fernández
- Department of Surgery, Hospital Universitario de Badajoz, 06006 Badajoz, Spain
- Enrique Dabán-Collado
- Department of Surgery, Hospital Universitario San Cecilio, 18016 Granada, Spain
- Miguel A. Gómez-Bravo
- Department of Surgery, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
- José I. Miota-de-Llamas
- Department of Surgery, Hospital Universitario de Albacete, 02006 Albacete, Spain
- Fernando Rotellar
- Department of Surgery, Clínica Universidad de Navarra, 31008 Pamplona, Spain
- Belinda Sánchez-Pérez
- Department of Surgery, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain
- Santiago Sánchez-Cabús
- Department of Surgery, Hospital Universitario de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
- David Pacheco-Sánchez
- Department of Surgery, Hospital Universitario Río Hortega, 47012 Valladolid, Spain
- Juan C. Rodríguez-Sanjuan
- Department of Surgery, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
- María A. Varona-Bosque
- Department of Surgery, Hospital Universitario Nuestra Señora de la Candelaria, 38010 Santa Cruz de Tenerife, Spain
- Lucía Carrión-Álvarez
- Department of Surgery, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain
- Sofía de la Serna-Esteban
- Department of Surgery, Hospital Clínico Universitario, 28040 Madrid, Spain
- Cristina Dopazo
- Department of Surgery, Hospital Universitario Vall d’Hebron, 08035 Barcelona, Spain
- Elena Martín-Pérez
- Department of Surgery, Hospital Universitario La Princesa, 28006 Madrid, Spain
- David Martínez-Cecilia
- Department of Surgery, Hospital Universitario La Princesa, 28006 Madrid, Spain
- María J. Castro-Santiago
- Department of Surgery, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain
- Dimitri Dorcaratto
- Department of Surgery, Hospital Clínico Universitario, 46010 Valencia, Spain
- Marta L. Gutiérrez-Díaz
- Department of Surgery, Hospital Quirón, 50006 Zaragoza, Spain
- José M. Asencio-Pascual
- Department of Surgery, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain
- Fernando Burdío-Pinilla
- Department of Surgery, Hospital Universitario del Mar, 08003 Barcelona, Spain
- Roberto Carracedo-Iglesias
- Department of Surgery, Hospital Universitario Álvaro Cunqueiro, 36312 Vigo, Spain
- Alfredo Escartín-Arias
- Department of Surgery, Hospital Universitario Arnau de Vilanova, 25198 Lleida, Spain
- Benedetto Ielpo
- Department of Surgery, Hospital Universitario del Mar, 08003 Barcelona, Spain
- Gonzalo Rodríguez-Laiz
- Department of Surgery, Hospital General Universitario Dr. Balmis, 03010 Alicante, Spain
- Andrés Valdivieso-López
- Department of Surgery, Hospital Universitario de Cruces, 48903 Barakaldo, Spain
- Emilio De-Vicente-López
- Department of Surgery, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain
- Vicente Alonso-Orduña
- Department of Medical Oncology, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
- José M. Ramia
- Department of Surgery, Hospital General Universitario Dr. Balmis, 03010 Alicante, Spain
- DOI
- https://doi.org/10.3390/cancers16091676
- Journal volume & issue
-
Vol. 16,
no. 9
p. 1676
Abstract
(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.
Keywords