Determination of toxicological relevant arsenic species in urine by hydride generation microwave-induced plasma optical emission spectrometry
Paulina Pizzorno,
Lucía Falchi,
Nelly Mañay,
Mariela Pistón,
Valery Bühl
Affiliations
Paulina Pizzorno
Centro Especializado en Química Toxicológica (CEQUIMTOX), Toxicology Area, DEC, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo, Uruguay; Grupo de Bioanalítica y Especiación (BIOESP), Analytical Chemistry Area, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo, Uruguay; Graduate Program in Chemistry, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo, Uruguay
Lucía Falchi
Grupo de Bioanalítica y Especiación (BIOESP), Analytical Chemistry Area, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo, Uruguay
Nelly Mañay
Centro Especializado en Química Toxicológica (CEQUIMTOX), Toxicology Area, DEC, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo, Uruguay
Mariela Pistón
Grupo de Análisis de Elementos Traza y Desarrollo de Estrategias Simples para Preparación de Muestras (GATPREM), Analytical Chemistry Area, DEC, Facultad de Química, Universidad de La República, Gral. Flores 2124, Montevideo, Uruguay
Valery Bühl
Grupo de Bioanalítica y Especiación (BIOESP), Analytical Chemistry Area, Facultad de Química, Universidad de la República, Gral. Flores 2124, Montevideo, Uruguay; Grupo de Análisis de Elementos Traza y Desarrollo de Estrategias Simples para Preparación de Muestras (GATPREM), Analytical Chemistry Area, DEC, Facultad de Química, Universidad de La República, Gral. Flores 2124, Montevideo, Uruguay; Corresponding author.
An analytical method for the determination of toxicological relevant species of arsenic in urine was developed and validated using hydride generation microwave-induced emission spectrometry (HG-MP-AES). This strategy can be used as an alternative to HG-HPLC-ICP-MS considered as a reference technique for arsenic speciation. This procedure is notably less expensive than other techniques and sample preparation and requires only a few steps. • Hydride generation with MP-AES detection has proven to be an effective technique for measuring arsenic metabolites in urine, which is relevant for occupational monitoring and health risk assessment purposes. • This method offers simplicity and cost-effectiveness, serving as an alternative to classical analytical procedures typically used for arsenic analysis in urine. • The methodology has been successfully applied for the purpose of workers' health surveillance.
