Diverse MR1-restricted T cells in mice and humans

Hui-Fern Koay; Nicholas A. Gherardin; Calvin Xu; Rebecca Seneviratna; Zhe Zhao; Zhenjun Chen; David P. Fairlie; James McCluskey; Daniel G. Pellicci; Adam P. Uldrich; Dale I. Godfrey

doi:10.1038/s41467-019-10198-w

Nature Communications (May 2019)

Diverse MR1-restricted T cells in mice and humans

Hui-Fern Koay,
Nicholas A. Gherardin,
Calvin Xu,
Rebecca Seneviratna,
Zhe Zhao,
Zhenjun Chen,
David P. Fairlie,
James McCluskey,
Daniel G. Pellicci,
Adam P. Uldrich,
Dale I. Godfrey

Affiliations

Hui-Fern Koay: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Nicholas A. Gherardin: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Calvin Xu: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Rebecca Seneviratna: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Zhe Zhao: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Zhenjun Chen: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
David P. Fairlie: Division of Chemistry & Structural Biology, Institute for Molecular Bioscience, The University of Queensland
James McCluskey: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Daniel G. Pellicci: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Adam P. Uldrich: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
Dale I. Godfrey: Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne

DOI: https://doi.org/10.1038/s41467-019-10198-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human peripheral blood.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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