The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing

Evi Goulielmaki; Maria Tsekrekou; Nikos Batsiotos; Mariana Ascensão-Ferreira; Eleftheria Ledaki; Kalliopi Stratigi; Georgia Chatzinikolaou; Pantelis Topalis; Theodore Kosteas; Janine Altmüller; Jeroen A. Demmers; Nuno L. Barbosa-Morais; George A. Garinis

doi:10.1038/s41467-021-23505-1

Nature Communications (May 2021)

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing

Evi Goulielmaki,
Maria Tsekrekou,
Nikos Batsiotos,
Mariana Ascensão-Ferreira,
Eleftheria Ledaki,
Kalliopi Stratigi,
Georgia Chatzinikolaou,
Pantelis Topalis,
Theodore Kosteas,
Janine Altmüller,
Jeroen A. Demmers,
Nuno L. Barbosa-Morais,
George A. Garinis

Affiliations

Evi Goulielmaki: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Maria Tsekrekou: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Nikos Batsiotos: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Mariana Ascensão-Ferreira: Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz
Eleftheria Ledaki: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Kalliopi Stratigi: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Georgia Chatzinikolaou: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Pantelis Topalis: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Theodore Kosteas: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
Janine Altmüller: Cologne Center for Genomics (CCG), Institute for Genetics, University of Cologne
Jeroen A. Demmers: Proteomics Center, Netherlands Proteomics Center, and Department of Biochemistry, Erasmus University Medical Center
Nuno L. Barbosa-Morais: Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz
George A. Garinis: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas

DOI: https://doi.org/10.1038/s41467-021-23505-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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XPA-binding protein (XAB)-2 is the human homologue of the yeast pre-mRNA splicing factor Syf1. Here the authors use an in vivo biotinylation tagging approach to show XAB2’s role in DNA repair, RNA splicing and transcription during mammalian development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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