Emerging roles of N6-methyladenosine in arsenic-induced toxicity
Rongxian Li,
Chaojie Wu,
Yuan Zhao,
Shiyi Jiang,
Junben Huang,
Xiuyun Huo,
Chang Deng,
Zuoshun He,
Shiyan Gu,
Jie Yang
Affiliations
Rongxian Li
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Chaojie Wu
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Yuan Zhao
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Shiyi Jiang
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Junben Huang
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Xiuyun Huo
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Chang Deng
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Zuoshun He
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China
Shiyan Gu
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China; Corresponding author. Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, 671000, Yunnan, China.
Jie Yang
College of Engineering, Dali University, Dali, Yunnan, China; Corresponding author. College of Engineering, Dali University, Dali 671000, Yunnan, China.
Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety of events. As the most common form of methylation modification of RNA in eukaryotic cells, N6-methyladenosine (m6A) is widely involved in regulating RNA processing, translation and degradation, thus playing important role in various pathophysiological processes. Emerging studies have demonstrated that m6A modification is synergistically mediated by methyltransferases, demethylases and methyl-binding proteins. Recently, emerging studies have shown that m6A modification and its regulatory proteins play important roles in arsenic toxicity through mediating various key signaling pathways. We comprehensively analyzed the mechanisms by which m6A modification and its regulatory proteins contribute to arsenic toxicity. Our reviews offer a scientific foundation for the development of preventive and control strategies to mitigate arsenic-induced toxicity, with an emphasis on an epigenetic approach.
