An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

Ming Jin; Brian O’Nuallain; Wei Hong; Justin Boyd; Valentina N. Lagomarsino; Tiernan T. O’Malley; Wen Liu; Charles R. Vanderburg; Matthew P. Frosch; Tracy Young-Pearse; Dennis J. Selkoe; Dominic M. Walsh

doi:10.1038/s41467-018-05068-w

Nature Communications (Jul 2018)

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

Ming Jin,
Brian O’Nuallain,
Wei Hong,
Justin Boyd,
Valentina N. Lagomarsino,
Tiernan T. O’Malley,
Wen Liu,
Charles R. Vanderburg,
Matthew P. Frosch,
Tracy Young-Pearse,
Dennis J. Selkoe,
Dominic M. Walsh

Affiliations

Ming Jin: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Brian O’Nuallain: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Wei Hong: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Justin Boyd: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Valentina N. Lagomarsino: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Tiernan T. O’Malley: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Wen Liu: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Charles R. Vanderburg: Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School
Matthew P. Frosch: Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School
Tracy Young-Pearse: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Dennis J. Selkoe: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Dominic M. Walsh: Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-05068-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the neuroprotective potential of several anti-Aβ antibodies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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