Phosphatidic acid: a lipid regulator of the Hippo pathway

Abstract

The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein interaction, providing additional insights into the Hippo-related tissue homeostasis and cancer development.

Keywords

• phospholipase d
• phosphatidic acid
• hippo pathway
• mtor