Nature Communications (Nov 2016)

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

  • Carolina Villarroya-Beltri,
  • Francesc Baixauli,
  • María Mittelbrunn,
  • Irene Fernández-Delgado,
  • Daniel Torralba,
  • Olga Moreno-Gonzalo,
  • Sara Baldanta,
  • Carlos Enrich,
  • Susana Guerra,
  • Francisco Sánchez-Madrid

DOI
https://doi.org/10.1038/ncomms13588
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Multivesicular bodies (MVB) are endosomal compartments that can either fuse with the plasma membrane for the secretion of exosomes, or fuse with the lysosome and be degraded along with their contents. Here, the authors show that ISGylation of the MVB protein TSG101 impairs exosome secretion and acts as a regulator of MVB fate.