The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Abstract

INTRODUCTION: The aim of this study was to assess vitamin D levels in obstructive sleep apnea syndrome (OSAS) and whether there is a relationship between the severity of the disease and vitamin D. METHODS: In this retrospective study, demographic data, serum 25-Hydroxycholecalciferol [25 (OH) D3], parathyroid hormone (PTH), calcium (Ca), phosphate (P), magnesium (Mg) levels and disease severity [mild, moderate and severe OSAS (AHI = 5-15, 16-30,> 30 / hour)] of patients diagnosed with OSAS by using polysomnography [apnea-hypopnea index (AHI> 5 / hour] and normal patients (AHI <5 / hour)] were evaluated based on hospital records. RESULTS: Of the 293 subjects whose records were examined, 229 had OSAS (mean age 55.7 +- 11.3 years; age range 26-86 years), whereas 64 subjects were normal (mean age 55.4 +- 13.7 years; age range 24-78 years). 25 (OH) D3 level was significantly lower while BMI and PTH levels were higher in OSAS patients compared to the control group (p <0.05). 25 (OH) D3 levels were significantly lower in patients with severe OSAS (p <0.05). In addition, there was a weak negative relationship between AHI and 25 (OH) D3 (p: 0.001, r: -0.328), while a weak positive relationship was observed between PTH (p: 0.001, r: 0.186) and BMI (p: 0.001, r: 0.208). DISCUSSION AND CONCLUSION: We think that vitamin D is deficient in OSAS patients, and vitamin D treatment may be beneficial in reducing the severity of the disease.

Keywords

• obstructive sleep apnea syndrome
• 25-hydroxyvitamin d
• relation