Nature Communications (Oct 2020)

Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

  • Marcel Tarbier,
  • Sebastian D. Mackowiak,
  • João Frade,
  • Silvina Catuara-Solarz,
  • Inna Biryukova,
  • Eleni Gelali,
  • Diego Bárcena Menéndez,
  • Luis Zapata,
  • Stephan Ossowski,
  • Magda Bienko,
  • Caroline J. Gallant,
  • Marc R. Friedländer

DOI
https://doi.org/10.1038/s41467-020-19011-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Gene expression covariation can be studied by single-cell RNA sequencing. Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and miRNA-induced covariation of target mRNAs.