Nature Communications (Feb 2017)
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination
- Yu Zheng,
- David T. Miyamoto,
- Ben S. Wittner,
- James P. Sullivan,
- Nicola Aceto,
- Nicole Vincent Jordan,
- Min Yu,
- Nezihi Murat Karabacak,
- Valentine Comaills,
- Robert Morris,
- Rushil Desai,
- Niyati Desai,
- Erin Emmons,
- John D. Milner,
- Richard J. Lee,
- Chin-Lee Wu,
- Lecia V. Sequist,
- Wilhelm Haas,
- David T. Ting,
- Mehmet Toner,
- Sridhar Ramaswamy,
- Shyamala Maheswaran,
- Daniel A. Haber
Affiliations
- Yu Zheng
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- David T. Miyamoto
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Ben S. Wittner
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- James P. Sullivan
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Nicola Aceto
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Nicole Vincent Jordan
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Min Yu
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Nezihi Murat Karabacak
- Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Valentine Comaills
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Robert Morris
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Rushil Desai
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Niyati Desai
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Erin Emmons
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- John D. Milner
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Richard J. Lee
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Chin-Lee Wu
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Lecia V. Sequist
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Wilhelm Haas
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- David T. Ting
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Mehmet Toner
- Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Sridhar Ramaswamy
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Shyamala Maheswaran
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- Daniel A. Haber
- Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/ncomms14344
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing the likelihood of metastasis formation.
