Nature Communications (Apr 2018)

HATRIC-based identification of receptors for orphan ligands

  • Nadine Sobotzki,
  • Michael A. Schafroth,
  • Alina Rudnicka,
  • Anika Koetemann,
  • Florian Marty,
  • Sandra Goetze,
  • Yohei Yamauchi,
  • Erick M. Carreira,
  • Bernd Wollscheid

DOI
https://doi.org/10.1038/s41467-018-03936-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Technologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million cells.