Ibn Al-Haitham Journal for Pure and Applied Sciences (May 2017)

Synthesis and Characterization of Some Amides Containing Isoxazoline Ring

  • Kh. F. Ali,
  • Dh. F Hussein,
  • J. H. Tomma

Journal volume & issue
Vol. 25, no. 3

Abstract

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This work involves synthesis of amides containing isoxazoline unit starting with chalcone; 4-[3-(3‾-nitrophenyl)-2-propene- 1-one]-aniline[I]. 4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen-schemidt reaction. The chalcone [I] was reacted with hydroxylamine hydrochloride giving isoxazoline [II] in NaOH basic medium. The amides with structural formula [III]a-h were prepared by the reaction of amino compounds ; isoxazoline [II] with different acid chlorides in dry pyridine and using DMF as a solvent at 4 0 C. All the synthesized compounds have been characterized by melting points , FTIR and 1 HMNR (of compound [III]a) spectroscopy.