Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Abstract

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure−activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.

Keywords

• chikungunya
• Euphorbiaceae
• phorbol
• tigliane
• daphnane
• ingenane
• jatrophane
• pre-myrsinane
• flexibilane
• PKC