Фармакокинетика и Фармакодинамика (Mar 2017)

Pharmacokinetic comparative study of tropoxine metabolite in miscellaneous animal species and humans

  • V. P. Zherdev,
  • G. B. Kolyvanov,
  • A. A. Litvin,
  • P. O. Bochkov,
  • R. V. Shevchenko,
  • O. G. Grybakina,
  • T. S. Ganshina

Journal volume & issue
Vol. 0, no. 2
pp. 30 – 34

Abstract

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Results of pharmacokinetic study of tropoxine metabolite (tropinone oxime; M-1) in experimental animals (rats, rabbits) and humans after administration several doses of tropoxine. Comparative analysis of the pharmacokinetic parameters characterizing of the metabolite formation intensity, i.e. Cmax of metabolite M-1 in the blood plasma increased in series: rats>humans> rabbits. Elimination rate of M-1 was decreased in series: rats>rabbits>humans

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