Фармакокинетика и Фармакодинамика (Mar 2017)
Pharmacokinetic comparative study of tropoxine metabolite in miscellaneous animal species and humans
Abstract
Results of pharmacokinetic study of tropoxine metabolite (tropinone oxime; M-1) in experimental animals (rats, rabbits) and humans after administration several doses of tropoxine. Comparative analysis of the pharmacokinetic parameters characterizing of the metabolite formation intensity, i.e. Cmax of metabolite M-1 in the blood plasma increased in series: rats>humans> rabbits. Elimination rate of M-1 was decreased in series: rats>rabbits>humans