1194 Mechanism of action of ivonescimab (AK112/SMT112): a first-in-class tetravalent Fc-silent bispecific antibody with dual blockade of PD-1 and VEGF that promotes cooperative biological effects

• Baiyong Li,
• Tingting Zhong,
• Zhaoliang Huang,
• Xinghua Pang,
• Chunshan Jin,
• Xinrong He,
• Jose Montoya,
• Betty Chang,
• Michelle Xia,
• Jing Min

Affiliations

Baiyong Li

1Akesobio, Zhongshan, Guangdong, China

Tingting Zhong

1Akesobio, Zhongshan, Guangdong, China

Zhaoliang Huang

1Akesobio, Zhongshan, Guangdong, China

Xinghua Pang

1Akesobio, Zhongshan, Guangdong, China

Chunshan Jin

1Akesobio, Zhongshan, Guangdong, China

Xinrong He

1Akesobio, Zhongshan, Guangdong, China

Jose Montoya

2Summit Therapeutics Inc, Menlo Park, CA, USA

Betty Chang

2Summit Therapeutics Inc, Menlo Park, CA, USA

Michelle Xia

1Akesobio, Zhongshan, Guangdong, China

Jing Min

1Akesobio, Zhongshan, Guangdong, China