Challenging assumptions about the demographics of eosinophilic gastrointestinal diseases: A systematic review

Mirna Chehade, MD, MPH; Benjamin L. Wright, MD; Samantha Walsh, MLS, MA; Dominique D. Bailey, MD; Amanda B. Muir, MD; Amy D. Klion, MD; Margaret H. Collins, MD; Carla M. Davis, MD; Glenn T. Furuta, MD; Sandeep Gupta, MD; Paneez Khoury, MD; Kathryn A. Peterson, MD; Elizabeth T. Jensen, PhD

Journal of Allergy and Clinical Immunology: Global (Aug 2024)

Challenging assumptions about the demographics of eosinophilic gastrointestinal diseases: A systematic review

Mirna Chehade, MD, MPH,
Benjamin L. Wright, MD,
Samantha Walsh, MLS, MA,
Dominique D. Bailey, MD,
Amanda B. Muir, MD,
Amy D. Klion, MD,
Margaret H. Collins, MD,
Carla M. Davis, MD,
Glenn T. Furuta, MD,
Sandeep Gupta, MD,
Paneez Khoury, MD,
Kathryn A. Peterson, MD,
Elizabeth T. Jensen, PhD

Affiliations

Mirna Chehade, MD, MPH: Departments of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, NY; Corresponding author: Mirna Chehade, MD, MPH, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029.
Benjamin L. Wright, MD: Department of Medicine, Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic Arizona, Section of Allergy and Immunology, Division of Pulmonology, Phoenix Children’s Hospital, Phoenix, Ariz
Samantha Walsh, MLS, MA: Departments of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, NY
Dominique D. Bailey, MD: Columbia University Vagelos College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children’s Hospital, New York, NY
Amanda B. Muir, MD: Department of Pediatrics and the Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Philadelphia, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pa
Amy D. Klion, MD: National Institute of Allergy and Infectious Diseases, Bethesda, Md
Margaret H. Collins, MD: Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio
Carla M. Davis, MD: Baylor College of Medicine, Texas Children’s Hospital, Houston, Tex
Glenn T. Furuta, MD: Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Children’s Hospital Colorado, Gastrointestinal Eosinophilic Disease Program, Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colo
Sandeep Gupta, MD: Indiana University School of Medicine, Indianapolis, Ind
Paneez Khoury, MD: National Institute of Allergy and Infectious Diseases, Bethesda, Md
Kathryn A. Peterson, MD: University of Utah Health, Salt Lake City, Utah
Elizabeth T. Jensen, PhD: Wake Forest University School of Medicine, Winston-Salem, NC

Journal volume & issue: Vol. 3, no. 3
p. 100260

Abstract

Read online

Background: The demographic characteristics of patients with eosinophilic gastrointestinal diseases (EGIDs) are poorly understood. Population-based assessments of EGID demographics may indicate health disparities in diagnosis. Objectives: We aimed to characterize the demographic distribution of EGIDs and evaluate the potential for bias in reporting patient characteristics. Methods: We conducted a systematic review, extracting data on age, sex, gender, race, ethnicity, body mass index, insurance, and urban/rural residence on EGID patients and the source population. Differences in proportions were assessed by chi-square tests. Demographic reporting was compared to recent guidelines. Results: Among 50 studies that met inclusion/exclusion criteria, 12 reported ≥1 demographic feature in both EGID and source populations. Except for age and sex or gender, demographics were rarely described (race = 4, ethnicity = 1, insurance = 1) or were not described (body mass index, urban/rural residence). A higher proportion of male subjects was observed for EoE or esophageal eosinophilia relative to the source population, but no difference in gender or sex distribution was observed for other EGIDs. “Sex” and “gender” were used interchangeably, and frequently only the male proportion was reported. Reporting of race and ethnicity was inconsistent with guidelines. Conclusion: Current data support a male predominance for EoE only. Evidence was insufficient to support enrichment of EGIDs in any particular racial, ethnic, or other demographic group. Population-based studies presenting demographics on both cases and source populations are needed. Implementation of guidelines for more inclusive reporting of demographic characteristics is crucial to prevent disparities in timely diagnosis and management of patients with EGIDs.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

About the journal

Abstract

Keywords