Nature Communications (Jul 2020)
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
- Weihua Zhou,
- Yangyang Yao,
- Andrew J. Scott,
- Kari Wilder-Romans,
- Joseph J. Dresser,
- Christian K. Werner,
- Hanshi Sun,
- Drew Pratt,
- Peter Sajjakulnukit,
- Shuang G. Zhao,
- Mary Davis,
- Barbara S. Nelson,
- Christopher J. Halbrook,
- Li Zhang,
- Francesco Gatto,
- Yoshie Umemura,
- Angela K. Walker,
- Maureen Kachman,
- Jann N. Sarkaria,
- Jianping Xiong,
- Meredith A. Morgan,
- Alnawaz Rehemtualla,
- Maria G. Castro,
- Pedro Lowenstein,
- Sriram Chandrasekaran,
- Theodore S. Lawrence,
- Costas A. Lyssiotis,
- Daniel R. Wahl
Affiliations
- Weihua Zhou
- Department of Radiation Oncology, University of Michigan
- Yangyang Yao
- Department of Radiation Oncology, University of Michigan
- Andrew J. Scott
- Department of Radiation Oncology, University of Michigan
- Kari Wilder-Romans
- Department of Radiation Oncology, University of Michigan
- Joseph J. Dresser
- Department of Radiation Oncology, University of Michigan
- Christian K. Werner
- Department of Radiation Oncology, University of Michigan
- Hanshi Sun
- Department of Radiation Oncology, University of Michigan
- Drew Pratt
- Department of Pathology, University of Michigan
- Peter Sajjakulnukit
- Department of Molecular and Integrative Physiology, University of Michigan
- Shuang G. Zhao
- Department of Radiation Oncology, University of Michigan
- Mary Davis
- Department of Radiation Oncology, University of Michigan
- Barbara S. Nelson
- Department of Molecular and Integrative Physiology, University of Michigan
- Christopher J. Halbrook
- Department of Molecular and Integrative Physiology, University of Michigan
- Li Zhang
- Department of Molecular and Integrative Physiology, University of Michigan
- Francesco Gatto
- Department of Biology and Biological Engineering, Chalmers University of Technology
- Yoshie Umemura
- Rogel Cancer Center, University of Michigan
- Angela K. Walker
- Biomedical Research Core Facilities, University of Michigan
- Maureen Kachman
- Biomedical Research Core Facilities, University of Michigan
- Jann N. Sarkaria
- Department of Radiation Oncology, Mayo Clinic
- Jianping Xiong
- Department of Oncology, the First Affiliated Hospital of Nanchang University
- Meredith A. Morgan
- Department of Radiation Oncology, University of Michigan
- Alnawaz Rehemtualla
- Department of Radiation Oncology, University of Michigan
- Maria G. Castro
- Rogel Cancer Center, University of Michigan
- Pedro Lowenstein
- Rogel Cancer Center, University of Michigan
- Sriram Chandrasekaran
- Rogel Cancer Center, University of Michigan
- Theodore S. Lawrence
- Department of Radiation Oncology, University of Michigan
- Costas A. Lyssiotis
- Rogel Cancer Center, University of Michigan
- Daniel R. Wahl
- Department of Radiation Oncology, University of Michigan
- DOI
- https://doi.org/10.1038/s41467-020-17512-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by inhibitors of purine synthesis.
